Nicotinic receptor activation induces NMDA receptor independent long-term potentiation of glutamatergic signalling in hippocampal oriens interneurons.

ABSTRACT:

Key points

Long-term potentiation of glutamatergic transmission to hippocampal interneurons in stratum oriens does not require NMDA receptors and the induction mechanisms are incompletely understood. Extracellular stimulation, conventionally used to monitor synaptic strength and induce long-term potentiation (LTP), does not exclusively recruit glutamatergic axons. We used optogenetic stimulation of either glutamatergic or cholinergic afferents to probe the relative roles of different signalling mechanisms in LTP induction. Selective stimulation of cholinergic axons was sufficient to induce LTP, which was prevented by chelating postsynaptic Ca²⁺ or blocking nicotinic receptors. The present study adds nicotinic receptors to the list of sources of Ca²⁺ that induc

SUBMITTER: Nicholson E 

PROVIDER: S-EPMC7839446 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature