Ketamine for Sickle Cell Vaso-Occlusive Crises: A Systematic Review.

ABSTRACT:

Introduction

Vaso-occlusive crisis (VOC) is one of the main causes of hospital admission in patients with sickle cell disease (SCD). Ketamine is often used as an adjuvant to opioids to control sickle cell crisis; however, there is a lack of evidence about its safety and efficacy for VOC in SCD patients.

Objective

To synthesize evidence from published reports about the efficacy and safety of ketamine in the management of acute painful VOC in both pediatric and adult SCD patients.

Methods

A systematic literature search of PubMed, Scopus, Web of Science, EBSCO and Cochrane Library was conducted, up to March 2019. Studies reporting the analgesic effects and side effects of ketamine in the management of acute painful VOC in pediatric and adult SCD patients were included. T

SUBMITTER: Alshahrani MS 

PROVIDER: S-EPMC7839575 | biostudies-literature | 2021 Jan-Apr

REPOSITORIES: biostudies-literature