Combined exposure to formaldehyde and PM_2.5: Hematopoietic toxicity and molecular mechanism in mice.

ABSTRACT: PM_2.5 and formaldehyde (FA) are major outdoor and indoor air pollutants in China, respectively, and both are known to be harmful to human health and to be carcinogenic. Of all the known chronic health effects, leukaemia is one of the most serious health risks associated with these two pollutants. To explore the influence and underlying mechanisms of exposure to formaldehyde and PM_2.5 on hematopoietic toxicity, we systematically studied the toxicity induced in hematopoietic organs: bone marrow (BM); spleen; and myeloid progenitor cells (MPCs). Male Balb/c mice were exposed to: PM_2.5 (20, 160 μg/kg·d) at a dose of 40 μL per mouse or formaldehyde (0.5, 3.0 mg/m³) for 8 h per day for 2 weeks or co-exposed to formaldehyde and PM_2.5 (20 μg/k

SUBMITTER: Ge J 

PROVIDER: S-EPMC7839661 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature