Single-Scan Selective Excitation of Individual NMR Signals in Overlapping Multiplets.

ABSTRACT: 2D NMR is an immensely powerful structural tool but it is time-consuming. Targeting individual chemical groups by selective excitation in a 1D experiment can give the information required far more quickly. A major problem, however, is that proton NMR spectra are often extensively overlapped, so that in practice only a minority of sites can be selectively excited. Here we overcome that problem using a fast, single-scan method that allows selective excitation of the signals of a single proton multiplet even where it is severely overlapped by other multiplets. The advantages of the method are illustrated in a selective 1D NOESY experiment, the most efficient way to determine relative configuration unambiguously by NMR. The new approach presented here has the potential to broaden significantly

SUBMITTER: Kiraly P 

PROVIDER: S-EPMC7839668 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature