Circulatory microRNAs as potential biomarkers for fatty liver disease: the Rotterdam study.

ABSTRACT:

Background

Fatty liver disease (FLD) is the most common cause of liver dysfunction in developed countries. There is great interest in developing clinically valid and minimally invasive biomarkers to enhance early diagnosis of FLD.

Aim

To investigate the potential of circulatory microRNAs (miRNAs) as biomarkers of FLD at the population level.

Methods

Plasma levels of 2083 miRNAs were measured by RNA sequencing in 1999 participants from the prospective population-based Rotterdam Study cohort. The Hounsfield Unit (HU) attenuation of liver was measured using non-enhanced computed tomography (CT) scan. Logistic and linear regression models adjusting for potential confounders were used to examine the association of circulatory miRNAs with liver enzymes (n = 1991) and CT-bas

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7839694 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature