Sleep deprivation as treatment for depression: Systematic review and meta-analysis.

ABSTRACT:

Objective

To systematically review evidence on the efficacy and safety of sleep deprivation (SD) as a treatment option for patients with unipolar or bipolar depression.

Methods

A systematic review according to PRISMA guidelines was conducted. The certainty of evidence was assessed using the GRADE approach. Controlled trials were included in efficacy analysis, case series for evaluating complications and qualitative studies for patients' experiences.

Results

Eight controlled studies (368 patients), one qualitative study and seven case series (825 patients) were included. One week after treatment start, SD combined with standard treatment did not reduce depressive symptoms compared with standard treatment (standardized mean difference, SMD = -0.29, [95% confidence inter

SUBMITTER: Ioannou M 

PROVIDER: S-EPMC7839702 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature