Kv11 (ether-a-go-go-related gene) voltage-dependent K⁺ channels promote resonance and oscillation of subthreshold membrane potentials.

ABSTRACT:

Key points

Some ion channels are known to behave as inductors and make up the parallel resonant circuit in the plasma membrane of neurons, which enables neurons to respond to current inputs with a specific frequency (so-called 'resonant properties'). Here, we report that heterologous expression of mouse Kv11 voltage-dependent K⁺ channels generate resonance and oscillation at depolarized membrane potentials in HEK293 cells; expressions of individual Kv11 subtypes generate resonance and oscillation with different frequency properties. Kv11.3-expressing HEK293 cells exhibited transient conductance changes that opposed the current changes induced by voltage steps; this probably enables Kv11 channels to behave like an inductor. The resonance and oscillation of inferior olivar

SUBMITTER: Matsuoka T 

PROVIDER: S-EPMC7839749 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature