Effects of oral semaglutide on energy intake, food preference, appetite, control of eating and body weight in subjects with type 2 diabetes.

ABSTRACT:

Aim

To evaluate the effect of oral semaglutide on energy intake and appetite in subjects with type 2 diabetes (T2D).

Materials and methods

In this randomized, double-blind, placebo-controlled, two-period cross-over trial, 15 subjects with T2D received 12 weeks of treatment with once-daily oral semaglutide (4-week dose escalation from 3 to 7 to 14 mg) followed by placebo, or vice versa. Energy intake was measured during an ad libitum lunch, evening meal and snack box after a standard breakfast. Appetite ratings were measured using a visual analogue scale after standard and fat-rich breakfasts. Other assessments included eating and craving control (using the Control of Eating Questionnaire), and changes in body weight and composition.

Results

Following a standard breakf

SUBMITTER: Gibbons C 

PROVIDER: S-EPMC7839771 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature