Association between renal failure and red blood cell alloimmunization among newly transfused patients.

ABSTRACT:

Background

Renal failure and renal replacement therapy (RRT) affect the immune system and could therefore modulate red blood cell (RBC) alloimmunization after transfusion.

Study design and methods

We performed a nationwide multicenter case-control study within a source population of newly transfused patients between 2005 and 2015. Using conditional multivariate logistic regression, we compared first-time transfusion-induced RBC alloantibody formers (N = 505) with two nonalloimmunized recipients with similar transfusion burden (N = 1010).

Results

Renal failure was observed in 17% of the control and 13% of the case patients. A total of 41% of the control patients and 34% of case patients underwent acute RRT. Renal failure without RRT was associated with lower alloimmuni

SUBMITTER: Oud JA 

PROVIDER: S-EPMC7839777 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature