Effects of Gut Microbiome on Carcinogenic DNA Damage.

ABSTRACT: The human intestine is host to a vast microbial community: the gut microbiome (GM). The GM has been considered as a key modulator of human health in the past decade. In particular, several studies have supported that altered GM is associated with cancer, such as colorectal cancer, adenocarcinoma, and pancreatic cancer. The formation of a DNA adduct is one of the key events in carcinogenesis, and whether GM can influence DNA adducts has yet to be examined. This study analyzed 10 DNA adducts (N²-Me-dG, N⁶-Me-dA, N²-Et-dG, OH-Me-dG, OH-Me-dA, N²-EtD-dG, O⁶-Me-dG, 1,N²-ε-dG, 8-oxo-dG, and 5-Cl-dC), attributed to various endogenous processes and physiological stressors, using highly sensitive LC-MS/MS in germ-free (GF) and conven

SUBMITTER: Hsiao YC 

PROVIDER: S-EPMC7839797 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature