COVID-19 increased the risk of ICU-acquired bloodstream infections: a case-cohort study from the multicentric OUTCOMEREA network.

ABSTRACT:

Purpose

The primary objective of this study was to investigate the risk of ICU bloodstream infection (BSI) in critically ill COVID-19 patients compared to non-COVID-19 patients. Subsequently, we performed secondary analyses in order to explain the observed results.

Methods

We conducted a matched case-cohort study, based on prospectively collected data from a large ICU cohort in France. Critically ill COVID-19 patients were matched with similar non-COVID-19 patients. ICU-BSI was defined by an infection onset occurring > 48 h after ICU admission. We estimated the effect of COVID-19 on the probability to develop an ICU-BSI using proportional subdistribution hazards models.

Results

We identified 321 COVID-19 patients and 1029 eligible controls in 6 ICUs. Finally, 235 COVI

SUBMITTER: Buetti N 

PROVIDER: S-EPMC7839935 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature