Activated protein C in neuroprotection and malaria.

ABSTRACT:

Purpose of review

Activated protein C (APC) is a homeostatic coagulation protease with anticoagulant and cytoprotective activities. Focusing on APC's effects in the brain, this review discusses three different scenarios that illustrate how APC functions are intimately affecting the physiology and pathophysiology of the brain.

Recent findings

Cytoprotective APC therapy holds promise for the treatment of ischemic stroke, and a recently completed trial suggested that cytoprotective-selective 3K3A-APC reduced bleeding in ischemic stroke patients. In contrast, APC's anticoagulant activity contributes to brain bleeding as shown by the disproportional upregulation of APC generation in cerebral cavernous malformations lesions in mice. However, too little APC generation also contribu

SUBMITTER: Mosnier LO 

PROVIDER: S-EPMC7840173 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature