Expression of xenobiotic metabolising enzymes in lungs of horses with or without histological evidence of lower airway inflammation.

ABSTRACT: Mild, moderate and severe equine asthma is a problem for equine welfare. The aetiology of the disease is not known in detail but is likely multi-factorial. One important factor may be inhaled dust which carries harmful substances which may be bioactivated and thus can lead to local inflammation in the airways. The aim of this study was to investigate gene expression and protein localisation of cytochrome P450 (CYP) enzymes, superoxide dismutase and glutathione-S-transferases (GST) involved in bioactivation and detoxification of harmful substances in lungs of horses with or without histological evidence of lower airway inflammation. Significantly lower gene expression of CYP2A13 and GSTM1 was observed in lungs from horses with histological evidence of lower airway inflammation compared with

SUBMITTER: Lofgren M 

PROVIDER: S-EPMC7840205 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature