The Early Response to Dietary Therapy can Predict the Late Outcome in Children with Intractable Epilepsy.

ABSTRACT:

Background and purpose

Dietary therapy (DT), including the ketogenic diet (KD), is one of the nonpharmacological treatment options for patient with drug-resistant epilepsy. However, maintaining DT in patients without seizure reduction is very difficult, so it is critical for clinicians to decide when to stop this intervention.

Methods

We retrospectively analyzed early clinical and laboratory findings and the clinical characteristics of children who received DT. The maintenance of DT and the clinical seizure frequency were assessed at 1, 3, 6, 12, and 24 months after KD initiation. Responders were defined as patients showing an overall reduction in seizure frequency of >50% relative to the baseline.

Results

We included 67 patients who received DT, but only 23 (34.3%) o

SUBMITTER: Lim SY 

PROVIDER: S-EPMC7840317 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature