Perilla (Perilla frutescens) leaf extract inhibits SARS-CoV-2 via direct virus inactivation.

ABSTRACT:

Background

While severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection presents with mild or no symptoms in most cases, a significant number of patients become critically ill. Remdesivir has been approved for the treatment of coronavirus disease 2019 (COVID-19) in several countries, but its use as monotherapy has not substantially lowered mortality rates. Because agents from traditional Chinese medicine (TCM) have been successfully utilized to treat pandemic and endemic diseases, we designed the current study to identify novel anti-SARS-CoV-2 agents from TCM.

Methods

We initially used an antivirus-induced cell death assay to screen a panel of herbal extracts. The inhibition of the viral infection step was investigated through a time-of-drug-addition assay, w

SUBMITTER: Tang WF 

PROVIDER: S-EPMC7840404 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature