Impact of Self-Association on the Architectural Properties of Bacterial Nucleoid Proteins.

ABSTRACT: The chromosomal DNA of bacteria is folded into a compact body called the nucleoid, which is composed essentially of DNA (∼80%), RNA (∼10%), and a number of different proteins (∼10%). These nucleoid proteins act as regulators of gene expression and influence the organization of the nucleoid by bridging, bending, or wrapping the DNA. These so-called architectural properties of nucleoid proteins are still poorly understood. For example, the reason why certain proteins compact the DNA coil in certain environments but make the DNA more rigid instead in other environments is the subject of ongoing debates. Here, we address the question of the impact of the self-association of nucleoid proteins on their architectural properties and try to determine whether differences in self-association are suff

SUBMITTER: Joyeux M 

PROVIDER: S-EPMC7840413 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature