Mechanics of Bacterial Interaction and Death on Nanopatterned Surfaces.

ABSTRACT: Nanopatterned surfaces are believed to kill bacteria through physical deformation, a mechanism that has immense potential against biochemical resistance. Because of its elusive nature, this mechanism is mostly understood through biophysical modeling. Problematically, accurate descriptions of the contact mechanics and various boundary conditions involved in the bacteria-nanopattern interaction remain to be seen. This may underpin conflicting predictions, found throughout the literature, regarding two important aspects of the mechanism-that is, its critical action site and relationship with geometry. Herein, a robust computational analysis of bacteria-nanopattern interaction is performed using a three-dimensional finite element modeling that incorporates relevant continuum mechanical propert

SUBMITTER: Velic A 

PROVIDER: S-EPMC7840415 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature