Modeling Thrombus Shell: Linking Adhesion Receptor Properties and Macroscopic Dynamics.

ABSTRACT: Damage to arterial vessel walls leads to the formation of platelet aggregate, which acts as a physical obstacle for bleeding. An arterial thrombus is heterogeneous; it has a dense inner part (core) and an unstable outer part (shell). The thrombus shell is very dynamic, being composed of loosely connected discoid platelets. The mechanisms underlying the observed mobility of the shell and its (patho)physiological implications are unclear. To investigate arterial thrombus mechanics, we developed a novel, to our knowledge, two-dimensional particle-based computational model of microvessel thrombosis. The model considers two types of interplatelet interactions: primary reversible (glycoprotein Ib (GPIb)-mediated) and stronger integrin-mediated interaction, which intensifies with platelet activat

SUBMITTER: Kaneva VN 

PROVIDER: S-EPMC7840445 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature