Homotopic redistribution of functional connectivity in insula-centered diffuse low-grade glioma.

ABSTRACT:

Objective

In the event of neural injury, the homologous contralateral brain areas may play a compensatory role to avoid or limit the functional loss. However, this dynamic strategy of functional redistribution is not clearly established, especially in the pathophysiological context of diffuse low-grade glioma. Our aim here was to assess the extent to which unilateral tumor infiltration of the insula dynamically modulates the functional connectivity of the contralesional one.

Methods

Using resting-state functional connectivity MRI, a seed-to-ROI approach was employed in 52 insula-centered glioma patients (n = 30 left and 22 right) compared with 19 age-matched healthy controls.

Results

Unsurprisingly, a significant decrease of the inter-insular connectivity was observed

SUBMITTER: Almairac F 

PROVIDER: S-EPMC7840474 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature