Mycobacterium avium Modulates the Protective Immune Response in Canine Peripheral Blood Mononuclear Cells.

ABSTRACT: Mycobacterium avium, an opportunistic intracellular pathogen, is a member of the non-tuberculous mycobacteria species. M. avium causes respiratory disease in immunosuppressed individuals and a wide range of animals, including companion dogs and cats. In particular, the number of infected companion dogs has increased, although the underlying mechanism of M. avium pathogenesis in dogs has not been studied. Therefore, in the present study, the host immune response against M. avium in dogs was investigated by transcriptome analysis of canine peripheral blood mononuclear cells. M. avium was shown to induce different immune responses in canine peripheral blood mononuclear cells at different time points after infection. The expression of Th1-associated genes occ

SUBMITTER: Kim S 

PROVIDER: S-EPMC7840563 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature