Immune Checkpoint Molecules-Inherited Variations as Markers for Cancer Risk.

ABSTRACT: In recent years, immunotherapy has been revolutionized by a new approach that works by blocking receptors called immune checkpoints (IC). These molecules play a key role in maintaining immune homeostasis, mainly by suppressing the immune response and by preventing its overactivation. Since inhibition of the immune response by IC can be used by cancer to avoid recognition and destruction by immune system, blocking them enhances the anti-tumor response. This therapeutic approach has brought spectacular clinical effects. The ICs present heterogeneous expression patterns on immune cells, which may affect the effectiveness of immunotherapy. The inherited genetic variants in regulatory regions of ICs genes can be considered as potential factors responsible for observed inter-individual differenc

SUBMITTER: Wagner M 

PROVIDER: S-EPMC7840570 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature