Cell properties assessment using optimized dielectrophoresis-based cell stretching and lumped mechanical modeling.

ABSTRACT: Cells mechanical property assessment has been a promising label-free method for cell differentiation. Several methods have been proposed for single-cell mechanical properties analysis. Dielectrophoresis (DEP) is one method used for single-cell mechanical property assessment, cell separation, and sorting. DEP method has overcome weaknesses of other techniques, including compatibility with microfluidics, high throughput assessment, and high accuracy. However, due to the lack of a general and explicit model for this method, it has not been known as an ideal cell mechanical property evaluation method. Here we present an explicit model using the most general electromagnetic equation (Maxwell Stress Tensor) for single-cell mechanical evaluation based on the DEP method. For proof of concept, we u

SUBMITTER: Hosseini II 

PROVIDER: S-EPMC7840762 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature