Total IgE as a Marker for Chronic Spontaneous Urticaria.

ABSTRACT:

Objective

Immunoglobulin E (IgE) and its receptor, FcɛRI, importantly contribute to the pathophysiology of chronic spontaneous urticaria (CSU). Recent findings point to a possible role of total IgE as a marker of CSU disease activity, endotypes, and responses to treatment. The evidence in support of total IgE included in the diagnostic workup of patients with CSU has not yet been reviewed.

Methods

Publications were searched via PubMed. The search terms used were "chronic urticaria" and "total IgE." Studies were screened by titles and abstracts, and 141 were used in the review.

Results

CSU patients frequently had elevated total IgE serum levels (up to 50%), but normal or very low total IgE levels also occurred. High total IgE may represent high disease activity, longer

SUBMITTER: Altrichter S 

PROVIDER: S-EPMC7840871 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature