Antivirulence Strategies for the Treatment of Staphylococcus aureus Infections: A Mini Review.

ABSTRACT: Staphylococcus aureus is a Gram-positive bacterium capable of infecting nearly all host tissues, causing severe morbidity and mortality. Widespread antimicrobial resistance has emerged among S. aureus clinical isolates, which are now the most frequent causes of nosocomial infection among drug-resistant pathogens. S. aureus produces an array of virulence factors that enhance in vivo fitness by liberating nutrients from the host or evading host immune responses. Staphylococcal virulence factors have been identified as viable therapeutic targets for treatment, as they contribute to disease pathogenesis, tissue injury, and treatment failure. Antivirulence strategies, or treatments targeting virulence without direct toxicity to the inciting pathogen, show promise as

SUBMITTER: Ford CA 

PROVIDER: S-EPMC7840885 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature