Low-dose Drosera rotundifolia induces gene expression changes in 16HBE human bronchial epithelial cells.

ABSTRACT: Drosera rotundifolia has been traditionally used for the treatment of respiratory diseases in phytotherapy and homeopathy. The mechanisms of action recognized so far are linked to the known effects of specific components, such as flavonoids, but are not completely understood. In this study, the biological functions of D. rotundifolia were explored in vitro following the treatment of bronchial epithelial cells, which are the potential targets of the pharmacological effects of the herbal medicine. To do so, the whole plant ethanolic extract was 1000-fold diluted in water (D. rotundifolia 3×) and added to a 16HBE human cell line culture for 3 h or 6 h. The effects on gene expression of the treatments and corresponding controls were then investigated by RNA sequencing. The differentially expre

SUBMITTER: Arruda-Silva F 

PROVIDER: S-EPMC7840928 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature