Complete sequences of Schizosaccharomyces pombe subtelomeres reveal multiple patterns of genome variation.

ABSTRACT: Genome sequences have been determined for many model organisms; however, repetitive regions such as centromeres, telomeres, and subtelomeres have not yet been sequenced completely. Here, we report the complete sequences of subtelomeric homologous (SH) regions of the fission yeast Schizosaccharomyces pombe. We overcame technical difficulties to obtain subtelomeric repetitive sequences by constructing strains that possess single SH regions of a standard laboratory strain. In addition, some natural isolates of S. pombe were analyzed using previous sequencing data. Whole sequences of SH regions revealed that each SH region consists of two distinct parts with mosaics of multiple common segments or blocks showing high variation among subtelomeres and strains. Subtelomere regions show relatively

SUBMITTER: Oizumi Y 

PROVIDER: S-EPMC7840980 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature