Renal interstitial fibroblasts coproduce erythropoietin and renin under anaemic conditions.

ABSTRACT:

Background

Erythrocyte mass contributes to maintaining systemic oxygen delivery and blood viscosity, with the latter being one of the determinants of blood pressure. However, the physiological response to blood pressure changes under anaemic conditions remain unknown.

Methods and findings

We show that anaemia decreases blood pressure in human patients and mouse models. Analyses of pathways related to blood pressure regulation demonstrate that anaemia enhances the expression of the gene encoding the vasopressor substance renin in kidneys. Although kidney juxtaglomerular cells are known to continuously produce renin, renal interstitial fibroblasts are identified in the present study as a novel site of renin induction under anaemic hypotensive conditions in mice and rats. Notab

SUBMITTER: Miyauchi K 

PROVIDER: S-EPMC7841315 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature