Rapid establishment of a COVID-19 critical care unit in a convention centre: the Nightingale Hospital London experience.
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SUBMITTER: Proudfoot AG
PROVIDER: S-EPMC7841382 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
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Rapid establishment of a COVID-19 critical care unit in a convention centre: the Nightingale Hospital London experience.
Proudfoot Alastair G AG O'Brien Ben B Schilling Richard R Gould Doug W DW McGlennan Alan A
Intensive care medicine 20210128 3
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Project description:ObjectiveTo assess the utility and frequency of use of the Nightingale Communication method, during the early operational phase of the Nightingale Hospital London 4000-bed field hospital Intensive Care Unit.DesignSurvey based cross sectional assessment.SettingThe intensive care unit at the Nightingale London hospital.ParticipantsStaff working in the clinical area, and therefore requiring full personal protective equipment.InterventionSurvey of all staff members sampled from a single shift at the Nightingale Hospital. This investigated perceived utility and actual use of identification methods (name and role labels on visors and gowns, coloured role identification tapes) and formal hand signals as an adjunctive communication method.Main outcome measureSelf reported frequency of use and perceived utility of each communication and personnel identification adjunct.Results50 valid responses were received (72% response rate) covering all clinical professional groups. Prominent name/role identifications and colour-coded identification tapes were very frequently used and were perceived as being highly useful. Formal hand signals were infrequently used, and not perceived as being beneficial, with respondents citing use of single taught gestures only in specific circumstances.ConclusionPPE is highly depersonalising and interpersonal identification aids are very useful. Despite being difficult, verbal communication is not completely prohibited, which could explain the low utility of formal hand signals. The methods developed at the Nightingale hospital have enhanced communication in the critical care, field hospital setting. There is potential for wider application to a variety of healthcare settings, in both the current situation and future pandemic scenarios.
| S-EPMC7799099 | biostudies-literature
Project description:The current global spread of COVID-19, a highly contagious disease, has challenged healthcare systems, and placed immense burdens on medical staff globally. With a sharp increase in the number of newly confirmed cases and the rapid progression of the disease into a critically ill state, overstretched critical care units have had to contend with a shortage of beds, specialist personnel, and medical resources. Temporary intensive care units (ICUs) were therefore set up in isolated hospitals to provide the required standardized care for all severe cases. The current paper describes the authors' experience of setting up and managing such an ICU in Wuhan, Hubei Province, China, from the identification of critically ill COVID-19 patients through to the arranging and equipping of the unit, providing training and protection for staff, and standardizing all aspects of care.
| S-EPMC7431884 | biostudies-literature
Project description:The COVID-19 pandemic has put the UK's National Health Service under extreme pressure, and acute psychiatric services have had to rapidly adapt to a new way of working. This editorial describes the experience of a London psychiatric intensive care unit (PICU) where all nine in-patients ultimately tested COVID-19 positive.
| S-EPMC7280557 | biostudies-literature
Project description:This paper describes the data that is collected and analysed annually by the Centre for Environment, Fisheries and Aquaculture Science (Cefas), on behalf of the United Kingdom (England, Scotland, Wales, Northern Ireland) and Jersey, Guernsey, and Isle of Man. The respective regulatory authorities provide data on the permits to dispose of dredged material that have been issued in a reporting year (January to December) as well as the amount of material that has been disposed within designated disposal sites within the same reporting year. The data are analysed to determine the contaminant loading that is placed at the respective disposal sites. Outputs from data analysis are submitted to international treaties (The Convention for the Protection of the Marine Environment of the North-East Atlantic and the London Convention/ London Protection) to determine progress towards the objectives of reducing pollution into the marine environment.
| S-EPMC9984411 | biostudies-literature
Project description:Ethiopia is a rapidly developing country in Eastern Africa. In total, 43.2% of the population are younger than 15. In contrast, until a few years ago, pediatric surgery was only available in Addis Ababa. Now, Ethiopia is making great efforts to improve the care of children who require surgery. JimmaChild was established to set up a pediatric surgery in Jimma. JimmaChild developed from a scientific collaboration between Jimma University (JU) and Ludwig-Maximilians-University. The project was developed and realized by Ethiopian and German colleagues. A curriculum was written for this purpose. The pediatric surgical training of the fellows was carried out on-site by German pediatric surgeons. A new pediatric surgery was established at JU with its own operating room, ward, and staff. After two and a half years, two fellows completed their final examinations as pediatric surgeons. Among others, 850 elective surgeries were performed, 82% assisted by the German colleagues. The German colleagues rated the preparation for the trip, the on-site support, and the professional progress of the fellows mostly as good to very good. Reported problems in the program flow were also recognized and solved in part. The best possible integration of the project into existing structures was achieved by close cooperation of Ethiopian and German colleagues during the project development. Problems were identified and addressed early on by external monitoring. As the project responsibility was mainly with the Ethiopian colleagues, a department was created that now exists independently of external funding and trains its own fellows.
| S-EPMC8005109 | biostudies-literature
Project description:IntroductionEmergency centres are most often the point of entry to the healthcare system for patients presenting with emergencies. Even though emergency medicine has developed rapidly in certain regions of South Africa, it is yet to flourish in the Eastern Cape. A paucity of data exists with regards to the demographic and disease profile of patients presenting to Eastern Cape emergency centres. This study describes the casemix presenting to a tertiary hospital emergency centre in East London in the Eastern Cape.MethodsA retrospective descriptive study was conducted of all patients presenting to Frere Hospital emergency centre from 1st of August 2019 to 31st of October 2019. Data were manually collected from the emergency centre paper-based register for the study period and included: patient demographics, geographical location, triage category, presenting complaint, disposition, and process times. Descriptive statistics were used to describe all variables.ResultsA total of 6 204 patients presented during the study period. The median age was 31 years, with a male predominance of 56%. Lower acuity triage categories (green and yellow) represented 67% of all cases. Trauma comprised 56% of all presentations, with assault being the most prevalent mechanism of injury in the adult population (n = 1 460, 48%). Sundays (18%) and Mondays (20%) had the highest patient caseload. The majority of patients were discharged home (n = 4 257, 69%) of which 79% had lower acuity triage categories. The majority of patients lived within a 20 km radius of Frere Hospital (n = 4 689, 77%).ConclusionThis descriptive study provides essential data that could guide further development of emergency care systems within the Eastern Cape. A high trauma burden, comprising predominantly of lower acuity presentations are described. Social and economic determinants of violence must be addressed and multisectoral interventions are required to reduce the high burden of trauma.
| S-EPMC9249588 | biostudies-literature
Project description:Rationale: A small but growing number of hospitals are experimenting with emergency department-embedded critical care units (CCUs) in an effort to improve the quality of care for critically ill patients with sepsis and acute respiratory failure (ARF).Objectives: To evaluate the potential impact of an emergency department-embedded CCU at the Hospital of the University of Pennsylvania among patients with sepsis and ARF admitted from the emergency department to a medical ward or intensive care unit (ICU) from January 2016 to December 2017.Methods: The exposure was eligibility for admission to the emergency department-embedded CCU, which was defined as meeting a clinical definition for sepsis or ARF and admission to the emergency department during the intervention period on a weekday. The primary outcome was hospital length of stay (LOS); secondary outcomes included total emergency department plus ICU LOS, hospital survival, direct admission to the ICU, and unplanned ICU admission. Primary interrupted time series analyses were performed using ordinary least squares regression comparing monthly means. Secondary retrospective cohort and before-after analyses used multivariable Cox proportional hazard and logistic regression.Results: In the baseline and intervention periods, 3,897 patients met the inclusion criteria for sepsis and 1,865 patients met the criteria for ARF. Among patients admitted with sepsis, opening of the emergency department-embedded CCU was not associated with hospital LOS (β = -1.82 d; 95% confidence interval [CI], -4.50 to 0.87; P = 0.17 for the first month after emergency department-embedded CCU opening compared with baseline; β = -0.26 d; 95% CI, -0.58 to 0.06; P = 0.10 for subsequent months). Among patients admitted with ARF, the emergency department-embedded CCU was not associated with a significant change in hospital LOS for the first month after emergency department-embedded CCU opening (β = -3.25 d; 95% CI, -7.86 to 1.36; P = 0.15) but was associated with a 0.64 d/mo shorter hospital LOS for subsequent months (β = -0.64 d; 95% CI, -1.12 to -0.17; P = 0.01). This result persisted among higher acuity patients requiring ventilatory support but was not supported by alternative analytic approaches. Among patients admitted with sepsis who did not require mechanical ventilation or vasopressors in the emergency department, the emergency department-embedded CCU was associated with an initial 9.9% reduction in direct ICU admissions in the first month (β = -0.099; 95% CI, -0.153 to -0.044; P = 0.002), followed by a 1.1% per month increase back toward baseline in subsequent months (β = 0.011; 95% CI, 0.003-0.019; P = 0.009). This relationship was supported by alternative analytic approaches and was not seen in ARF. No associations with emergency department plus ICU LOS, hospital survival, or unplanned ICU admission were observed among patients with sepsis or ARF.Conclusions: The emergency department-embedded CCU was not associated with clinical outcomes among patients admitted with sepsis or ARF. Among less sick patients with sepsis, the emergency department-embedded CCU was initially associated with reduced rates of direct ICU admission from the emergency department. Additional research is necessary to further evaluate the impact and utility of the emergency department-embedded CCU model.
| S-EPMC7706601 | biostudies-literature
Project description:BackgroundThis study aims to compare the outcomes of COVID-19-positive disease in patients with a history of cancer to those without.MethodsWe retrospectively collected clinical data and outcomes of COVID-19 positive cancer patients treated consecutively in five North London hospitals (cohort A). Outcomes recorded included time interval between most recent anti-cancer treatment and admission, severe outcome [a composite endpoint of intensive care unit (ITU) admission, ventilation and/or death] and mortality. Outcomes were compared with consecutively admitted COVID-19 positive patients, without a history of cancer (cohort B), treated at the primary centre during the same time period (1 March-30 April 2020). Patients were matched for age, gender and comorbidity.ResultsThe median age in both cohorts was 74 years, with 67% male, and comprised of 30 patients with cancer, and 90 without (1:3 ratio). For cohort B, 579 patients without a history of cancer and consecutively admitted were screened from the primary London hospital, 105 were COVID-19 positive and 90 were matched and included. Excluding cancer, both cohorts had a median of two comorbidities. The odds ratio (OR) for mortality, comparing patients with cancer to those without, was 1.05 [95% confidence interval (CI) 0.4-2.5], and severe outcome (OR 0.89, 95% CI 0.4-2.0) suggesting no increased risk of death or a severe outcome in patients with cancer. Cancer patients who received systemic treatment within 28 days had an OR for mortality of 4.05 (95% CI 0.68-23.95), p = 0.12. On presentation anaemia, hypokalaemia, hypoalbuminaemia and hypoproteinaemia were identified predominantly in cohort A. Median duration of admission was 8 days for cancer patients and 7 days for non-cancer.ConclusionA diagnosis of cancer does not appear to increase the risk of death or a severe outcome in COVID-19 patients with cancer compared with those without cancer. If a second spike of virus strikes, rational decision making is required to ensure optimal cancer care.
| S-EPMC7493246 | biostudies-literature
Project description:BackgroundUsing an updated dataset with more patients and extended follow-up, we further established cancer patient characteristics associated with COVID-19 death.MethodsData on all cancer patients with a positive reverse transcription-polymerase chain reaction swab for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) at Guy's Cancer Centre and King's College Hospital between 29 February and 31 July 2020 was used. Cox proportional hazards regression was performed to identify which factors were associated with COVID-19 mortality.ResultsThree hundred and six SARS-CoV-2-positive cancer patients were included. Seventy-one had mild/moderate and 29% had severe COVID-19. Seventy-two patients died of COVID-19 (24%), of whom 35 died <7 days. Male sex [hazard ratio (HR): 1.97 (95% confidence interval (CI): 1.15-3.38)], Asian ethnicity [3.42 (1. 59-7.35)], haematological cancer [2.03 (1.16-3.56)] and a cancer diagnosis for >2-5 years [2.81 (1.41-5.59)] or ≥5 years were associated with an increased mortality. Age >60 years and raised C-reactive protein (CRP) were also associated with COVID-19 death. Haematological cancer, a longer-established cancer diagnosis, dyspnoea at diagnosis and raised CRP were indicative of early COVID-19-related death in cancer patients (<7 days from diagnosis).ConclusionsFindings further substantiate evidence for increased risk of COVID-19 mortality for male and Asian cancer patients, and those with haematological malignancies or a cancer diagnosis >2 years. These factors should be accounted for when making clinical decisions for cancer patients.
| S-EPMC8366163 | biostudies-literature
Project description:ProblemIntroduction and evaluation of evidence based medicine (EBM) into routine hospital practice.Strategy for changeRoutine EBM meetings introduced in 1997.DesignReview of outcomes of meetings from 1997 to 2004, focusing on their effect on clinical practice.SettingReferral centre for tropical and domestic infectious diseases. KEY MEASURE FOR IMPROVEMENT: Outcome of meetings, classified as resulting in a change in practice; confirmation or clarification of existing practice; identification of a need for more evidence; and outcome unclear.Effects of changeExamples include a change from inpatient to day case treatment of New World cutaneous leishmaniasis; development of guidelines on the treatment of coinfection with visceral leishmaniasis and HIV; and identification of the need for more data on the efficacy and toxicity of atovaquone-proguanil (Malarone) compared with quinine plus sulfadoxine-pyrimethamine (Fansidar) in the treatment of uncomplicated falciparum malaria, which resulted in a clinical trial being set up.Lessons learntIncorporation of EBM meetings into our routine practice has resulted in treatment guidelines being more closely based on published evidence and improvements to care of patients. Written summaries of the meetings are important to facilitate change.
| S-EPMC524557 | biostudies-literature