Altered structural connectome in non-lesional newly diagnosed focal epilepsy: Relation to pharmacoresistance.

ABSTRACT: Despite an expanding literature on brain alterations in patients with longstanding epilepsy, few neuroimaging studies investigate patients with newly diagnosed focal epilepsy (NDfE). Understanding brain network impairments at diagnosis is necessary to elucidate whether or not brain abnormalities are principally due to the chronicity of the disorder and to develop prognostic markers of treatment outcome. Most adults with NDfE do not have MRI-identifiable lesions and the reasons for seizure onset and refractoriness are unknown. We applied structural connectomics to T1-weighted and multi-shell diffusion MRI data with generalized q-sampling image reconstruction using Network Based Statistics (NBS). We scanned 27 patients within an average of 3.7 (SD = 2.9) months of diagnosis and anti-epilepti

SUBMITTER: Kreilkamp BAK 

PROVIDER: S-EPMC7841400 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature