S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis.

ABSTRACT:

Background & aims

Nonalcoholic fatty liver disease (NAFLD) is becoming a severe liver disorder worldwide. Autophagy plays a critical role in liver steatosis. However, the role of autophagy in NAFLD remains exclusive and under debate. In this study, we investigated the role of S100 calcium binding protein A11 (S100A11) in the pathogenesis of hepatic steatosis.

Methods

We performed liver proteomics in a well-established tree shrew model of NAFLD. The expression of S100A11 in different models of NAFLD was detected by Western blot and/or quantitative polymerase chain reaction. Liver S100A11 overexpression mice were generated by injecting a recombinant adenovirus gene transfer vector through the tail vein and then induced by a high-fat and high-cholesterol diet. Cell lines with S

SUBMITTER: Zhang L 

PROVIDER: S-EPMC7841444 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature