Identification of two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis patients.

ABSTRACT:

Background

Optic neuritis (ON) can occur as an isolated episode or will develop to multiple sclerosis (MS) a chronic autoimmune disease. What predicts ON progression to MS remains poorly understood.

Methods

We characterised the antibody epitope repertoire in three independent clinical cohorts (discovery (n = 62), validation (n = 20) and external cohort (n = 421)) using mimotope variation analysis (MVA), a next generation phage display technology to identify epitopes that associate with prognosis of ON.

Findings

We observed distinct epitope profiles for ON, MS and the controls, whereas epitope repertoires of sera and CSF were highly similar. Two unique and highly immunogenic epitopes A and B were detected in subjects with ON progressing to MS. These epitopes A and B we

SUBMITTER: Sadam H 

PROVIDER: S-EPMC7841498 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature