A preliminary study of cytokine gene polymorphism effects on Saudi patients with colorectal cancer.

ABSTRACT:

Objective

 To determine the possible associations of polymorphisms in interleukin (IL)-8 (rs4073 T/A), IL-10 (rs1800896 A/G), IL-22 (rs1179251 C/G and rs2227485 C/T), IL-27 (rs17855750 T/G), and transforming growth factor beta 1 (TGFß1) (rs1800469 C/T) with colorectal cancer (CRC) susceptibility in Saudi patients.

Methods

The case-control study was carried out between July 2019 and January 2020 in King Khaled University Hospital, Riyadh, Saudi Arabia. A total of 70 patients with CRC and 70 healthy controls were included  in  the  study.  Single nucleotide polymorphisms of promoter regions were determined using TaqMan genotyping assays.

Results

 A statistically significant reduction in CRC risk was identified for carriers of the IL-10 (rs1800896 A/G) AG genotype, IL-22

SUBMITTER: Althubyani SA 

PROVIDER: S-EPMC7841582 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature