Insulin resistance in transgender individuals correlates with android fat mass.

ABSTRACT:

Background

Transgender individuals receiving gender-affirming hormone therapy (GAHT) are at increased risk of adverse cardiovascular outcomes. This may be related to effects on body composition and insulin resistance.

Aims

To examine relationships between body fat distribution and insulin resistance in transgender individuals on established GAHT.

Methods

Comparisons of body composition (dual energy X-ray absorptiometry) and insulin resistance [Homeostasis Model of Insulin Resistance (HOMA2-IR)] were made between transgender individuals (43 trans men and 41 trans women) on established GAHT (>12 months) and age-matched cisgender controls (30 males and 48 females). Multiple linear regressions were used to examine the relationship between HOMA2-IR and fat mass with gender

SUBMITTER: Bretherton I 

PROVIDER: S-EPMC7841663 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature