Hormonal Treatments for Major Depressive Disorder: State of the Art.

ABSTRACT: Major depressive disorder is a common psychiatric disorder associated with marked suffering, morbidity, mortality, and cost. The World Health Organization projects that by 2030, major depression will be the leading cause of disease burden worldwide. While numerous treatments for major depression exist, many patients do not respond adequately to traditional antidepressants. Thus, more effective treatments for major depression are needed, and targeting certain hormonal systems is a conceptually based approach that has shown promise in the treatment of this disorder. A number of hormones and hormone-manipulating compounds have been evaluated as monotherapies or adjunctive treatments for major depression, with therapeutic actions attributable not only to the modulation of endocrine systems in

SUBMITTER: Dwyer JB 

PROVIDER: S-EPMC7841732 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature