Modification of vitamin B6 on the associations of blood lead levels and cardiovascular diseases in the US adults.

ABSTRACT:

Background

Cardiovascular disease (CVD) is a leading cause of death in the US population. Lead exposure is an important risk factor of CVDs, as is associated with elevated homocysteine level and oxidative stress. We aim to examine whether vitamin B6, which has been shown to reduce homocysteine level, can modify the relationship between blood lead and the risk of CVDs.

Methods

Cross-sectional data on ever-report CVDs (congestive heart failure, coronary heart disease, angina pectoris, heart attack and stroke), blood lead level (BLL) and vitamin B6 in the form of plasma pyridoxal 5'-phosphate were obtained from US National Health and Nutrition Examination Survey 2005-2006 for adults≥20 years old. The association between CVDs and quartiles of BLL was estimated using multivariate

SUBMITTER: Wei J 

PROVIDER: S-EPMC7841818 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature