Inferring time series chromatin states for promoter-enhancer pairs based on Hi-C data.

ABSTRACT:

Background

Co-localized combinations of histone modifications ("chromatin states") have been shown to correlate with promoter and enhancer activity. Changes in chromatin states over multiple time points ("chromatin state trajectories") have previously been analyzed at promoter and enhancers separately. With the advent of time series Hi-C data it is now possible to connect promoters and enhancers and to analyze chromatin state trajectories at promoter-enhancer pairs.

Results

We present TimelessFlex, a framework for investigating chromatin state trajectories at promoters and enhancers and at promoter-enhancer pairs based on Hi-C information. TimelessFlex extends our previous approach Timeless, a Bayesian network for clustering multiple histone modification data sets at promote

SUBMITTER: Miko H 

PROVIDER: S-EPMC7841892 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature