Plasma sex hormones and risk of conventional and serrated precursors of colorectal cancer in postmenopausal women.

ABSTRACT:

Background

Sex hormones have been suggested to play a role in colorectal cancer (CRC), but their influence on early initiation of CRC remains unknown.

Methods

We retrospectively examined the associations with risk of CRC precursors, including conventional adenomas and serrated polyps, for plasma estrone, estradiol, free estradiol, testosterone, free testosterone, sex hormone-binding globulin (SHBG), and the ratio of estradiol to testosterone among 5404 postmenopausal women from the Nurses' Health Study I and II. Multivariable logistic regression was used to calculate the odds ratio (OR) and 95% confidence intervals (CI). Given multiple testing, P < 0.005 was considered statistically significant.

Results

During 20 years of follow-up, we documented 535 conventional aden

SUBMITTER: Hang D 

PROVIDER: S-EPMC7841996 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature