Metabolic profile distinguishes laminitis-susceptible and -resistant ponies before and after feeding a high sugar diet.

ABSTRACT:

Background

Insulin dysregulation (ID) is a key risk factor for equine endocrinopathic laminitis, but in many cases ID can only be assessed accurately using dynamic tests. The identification of other biomarkers could provide an alternative or adjunct diagnostic method, to allow early intervention before laminitis develops. The present study characterised the metabolome of ponies with varying degrees of ID using basal and postprandial plasma samples obtained during a previous study, which examined the predictive power of blood insulin levels for the development of laminitis, in ponies fed a high-sugar diet. Samples from 10 pre-laminitic (PL - subsequently developed laminitis) and 10 non-laminitic (NL - did not develop laminitis) ponies were used in a targeted metabolomic assay. Diffe

SUBMITTER: Delarocque J 

PROVIDER: S-EPMC7841998 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature