Tumor mutation burden in connection with immune-related survival in uterine corpus endometrial carcinoma.

ABSTRACT:

Background

UCEC is the most common gynecological malignancy in many countries, and its mechanism of occurrence and development is related to tumor mutation burden (TMB) and immune cell infiltration. Therefore, it is necessary to systematically explore the TMB-related gene profile in immune cells to improve the prognosis of UCEC.

Methods

We integrated TMB-related genes with basic clinical information of UCEC patients based on TCGA dataset. Differentially expressed genes (DEGs) were selected through differential expression screening, PPI, and enrichment analysis. Additionally, we analyzed the components of immune cell infiltration of the DEGs to obtain the differential immunity-related genes. A single factor and multifactor Cox regression analyses were conducted to establish n

SUBMITTER: Zhao L 

PROVIDER: S-EPMC7842022 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature