Metabolomic profiles of plasma and uterine luminal fluids from healthy and repeat breeder Holstein cows.

ABSTRACT:

Background

Repeat breeding is a critical reproductive disorder in cattle. The problem of repeat breeder cattle remains largely unmanageable due to a lack of informative biomarkers. Here, we utilized metabolomic profiling in an attempt to identify metabolites in the blood plasma and uterine luminal fluids. We collected blood and uterine fluid from repeat breeder and healthy cows on day 7 of the estrous cycle.

Results

Metabolomic analysis identified 17 plasma metabolites detected at concentrations that distinguished between the two groups, including decreased various bile acids among the repeat breeders. However, no metabolites that varied significantly were detected in the uterine luminal fluids between two groups. Among the plasma samples, kynurenine was identified as underg

SUBMITTER: Funeshima N 

PROVIDER: S-EPMC7842029 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature