Predicting in vivo absorption of chloramphenicol in frogs using in vitro percutaneous absorption data.

ABSTRACT:

Background

Infectious disease, particularly the fungal disease chytridiomycosis (caused by Batrachochytrium dendrobatidis), is a primary cause of amphibian declines and extinctions worldwide. The transdermal route, although offering a simple option for drug administration in frogs, is complicated by the lack of knowledge regarding percutaneous absorption kinetics. This study builds on our previous studies in frogs, to formulate and predict the percutaneous absorption of a drug for the treatment of infectious disease in frogs. Chloramphenicol, a drug with reported efficacy in the treatment of infectious disease including Batrachochytrium dendrobatidis, was formulated with 20% v/v propylene glycol and applied to the ventral pelvis of Rhinella marina for up to 6 h. Serum samples were

SUBMITTER: Llewelyn VK 

PROVIDER: S-EPMC7842057 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature