A Genome-Wide Association Study of Childhood Body Fatness.

ABSTRACT:

Objective

This study aimed to uncover genetic contributors to adiposity in early life.

Methods

A genome-wide association study of childhood body fatness in 34,401 individuals within the Nurses' Health Studies and the Health Professionals Follow-up Study was conducted. Data were imputed to the 1000 Genomes Phase 3 version 5 reference panel.

Results

A total of 1,354 single-nucleotide polymorphisms (P < 10^-4 ) were selected for replication in a previously published genome-wide association study of childhood BMI. Nineteen significant genome-wide (P < 5 × 10^-8 ) regions were observed, fourteen of which were previously associated with childhood obesity and five were novel: BNDF (P = 7.58 × 10^-13 ), PRKD1 (P = 1.43 × 10^-10 ), 20p13

SUBMITTER: Warner ET 

PROVIDER: S-EPMC7842657 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature