Why Are Women Less Represented in Intracerebral Hemorrhage Trials?

ABSTRACT:

Background and purpose

Fewer women than men tend to be enrolled in clinical trials of intracerebral hemorrhage. It is unclear whether this reflects lower prevalence of intracerebral hemorrhage in women, selection bias, or poor recruitment efforts. We undertook this study to examine differences between men and women in the reasons for exclusion from the iDEF trial (Intracerebral Hemorrhage Deferoxamine).

Methods

The screen failure log included 29 different reasons for exclusion. Chi-square statistics were used to evaluate the differences in reasons for exclusion between men and women.

Results

A total of 38.2% of participants in iDEF were women. Three thousand nine hundred eighty-two women (45.7%) and 4736 men (54.3%) were screen failures (P<0.0001). Similar prop

SUBMITTER: Greige T 

PROVIDER: S-EPMC7842663 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature