Tet1 Isoforms Differentially Regulate Gene Expression, Synaptic Transmission, and Memory in the Mammalian Brain.

ABSTRACT: The dynamic regulation of DNA methylation in postmitotic neurons is necessary for memory formation and other adaptive behaviors. Ten-eleven translocation 1 (TET1) plays a part in these processes by oxidizing 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), thereby initiating active DNA demethylation. However, attempts to pinpoint its exact role in the nervous system have been hindered by contradictory findings, perhaps due in part, to a recent discovery that two isoforms of the Tet1 gene are differentially expressed from early development into adulthood. Here, we demonstrate that both the shorter transcript (Tet1^S ) encoding an N-terminally truncated TET1 protein and a full-length Tet1 (Tet1^FL ) transcript encoding canonical TET1 a

SUBMITTER: Greer CB 

PROVIDER: S-EPMC7842754 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature