Epithelial cell-turnover ensures robust coordination of tissue growth in Drosophila ribosomal protein mutants.

ABSTRACT: Highly reproducible tissue development is achieved by robust, time-dependent coordination of cell proliferation and cell death. To study the mechanisms underlying robust tissue growth, we analyzed the developmental process of wing imaginal discs in Drosophila Minute mutants, a series of heterozygous mutants for a ribosomal protein gene. Minute animals show significant developmental delay during the larval period but develop into essentially normal flies, suggesting there exists a mechanism ensuring robust tissue growth during abnormally prolonged developmental time. Surprisingly, we found that both cell death and compensatory cell proliferation were dramatically increased in developing wing pouches of Minute animals. Blocking the cell-turnover by inhibiting cell death resulted in morpholog

SUBMITTER: Akai N 

PROVIDER: S-EPMC7842893 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature