Voxelized simulation of cerebral oxygen perfusion elucidates hypoxia in aged mouse cortex.

ABSTRACT: Departures of normal blood flow and metabolite distribution from the cerebral microvasculature into neuronal tissue have been implicated with age-related neurodegeneration. Mathematical models informed by spatially and temporally distributed neuroimage data are becoming instrumental for reconstructing a coherent picture of normal and pathological oxygen delivery throughout the brain. Unfortunately, current mathematical models of cerebral blood flow and oxygen exchange become excessively large in size. They further suffer from boundary effects due to incomplete or physiologically inaccurate computational domains, numerical instabilities due to enormous length scale differences, and convergence problems associated with condition number deterioration at fine mesh resolutions. Our proposed sim

SUBMITTER: Hartung G 

PROVIDER: S-EPMC7842915 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature