Switched and unswitched memory B cells detected during SARS-CoV-2 convalescence correlate with limited symptom duration.

ABSTRACT: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of the pandemic human respiratory illness COVID-19, is a global health emergency. While severe acute disease has been linked to an expansion of antibody-secreting plasmablasts, we sought to identify B cell responses that correlated with positive clinical outcomes in convalescent patients. We characterized the peripheral blood B cell immunophenotype and plasma antibody responses in 40 recovered non-hospitalized COVID-19 subjects that were enrolled as donors in a convalescent plasma treatment study. We observed a significant negative correlation between the frequency of peripheral blood memory B cells and the duration of symptoms for convalescent subjects. Memory B cell subsets in convalescent subjects were com

SUBMITTER: Newell KL 

PROVIDER: S-EPMC7843013 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature