An unbiased approach to defining bona fide cancer neoepitopes that elicit immune-mediated cancer rejection.

ABSTRACT: Identification of neoepitopes that are effective in cancer therapy is a major challenge in creating cancer vaccines. Here, using an entirely unbiased approach, we queried all possible neoepitopes in a mouse cancer model and asked which of those are effective in mediating tumor rejection and, independently, in eliciting a measurable CD8 response. This analysis uncovered a large trove of effective anticancer neoepitopes that have strikingly different properties from conventional epitopes and suggested an algorithm to predict them. It also revealed that our current methods of prediction discard the overwhelming majority of true anticancer neoepitopes. These results from a single mouse model were validated in another antigenically distinct mouse cancer model and are consistent with data report

SUBMITTER: Brennick CA 

PROVIDER: S-EPMC7843235 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature