Clinical significance of the serum IgM and IgG to SARS-CoV-2 in coronavirus disease-2019.

ABSTRACT:

Objective

To explore the clinical value of serum IgM and IgG to SARS-CoV-2 in COVID-19.

Methods

105 COVID-19 patients were enrolled as the disease group. 197 non-COVID-19 patients served as the control group. Magnetic chemiluminescent immunoassay (MCLIA) was used to detect the IgM and IgG.

Results

The peak of positive rates of SARS-CoV-2 IgM was about 1 week earlier than that of IgG. It reached to peak within 15-21 days and then began a slowly decline. The positive rates of IgG were increased with the disease course and reached the peak between 22 and 39 days. The differences in sensitivity of the three detection modes (IgM, IgG, and IgM + IgG) were statistically significant. The largest group of test cases (illness onset 15-21 days) showed that the positive rate of I

SUBMITTER: Wu LX 

PROVIDER: S-EPMC7843265 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature