Proteolytic cleavage of HLA class II by human neutrophil elastase in pneumococcal pneumonia.

ABSTRACT: Bacterial and viral respiratory infections can initiate acute lung injury and acute respiratory distress syndrome. Neutrophils and their granule enzymes, including neutrophil elastase, are key mediators of the pathophysiology of acute respiratory failure. Although intracellular neutrophil elastase functions as a host defensive factor against pathogens, its leakage into airway spaces induces degradation of host connective tissue components. This leakage disrupts host innate immune responses via proteolytic cleavage of Toll-like receptors and cytokines. Here, we investigated whether neutrophils possess proteases that cleave adaptive immune molecules. We found that expression of the human leukocyte antigen (HLA) class II molecule HLA-DP β1 was decreased in THP-1-derived macrophages treated wi

SUBMITTER: Domon H 

PROVIDER: S-EPMC7843615 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature